US Secretary of State John Kerry has said Syrian President Bashar al-Assad would have no role in a political settlement to Syria's conflict.
The comments followed reports that the US was softening its insistence on Mr Assad's departure as a precondition for any deal - as demanded by rebels.
That had been opposed by Russia, which this week agreed to convene an international conference on Syria.
Meanwhile, Jordan said Syrian refugees now make up 10% of its population.
Foreign Minister Nasser Judeh said that by the end of the year that figure could reach 25%, and 40% by mid-2014.
Mr Kerry announced a further $100m (£64m) in aid for Syrian refugees, $43m of which would go to Jordan.
'Very positive response'Speaking to reporters in Rome, Mr Kerry said Mr Nasser would work with the US to "effect a transition government by mutual consent of both sides, which clearly means that in our judgement President Assad will not be a component of that transitional government".
Mr Kerry also said there had been a "very positive response" to the US-Russian proposal for an international conference on Syria, announced after Mr Kerry held talks in Moscow with President Vladimir Putin and Foreign Minister Sergei Lavrov.
The forum will try to persuade both the Syrian government and opposition to accept a solution based on the core elements of the final communique issued after the UN-backed Action Group for Syria meeting in Geneva last June.
The communique called for an immediate cessation of violence and the establishment of a transitional government that could include officials serving under President Bashar al-Assad and members of the opposition.
"We are going to forge ahead very, very directly to work with all of the parties to bring that conference together," Mr Kerry said on Thursday.
The UN-Arab League envoy for Syria, Lakhdar Brahimi, said the deal was "the first hopeful news" on Syria for a long time, but cautioned that it was "only a first step".
More than 70,000 people are estimated to have been killed since the uprising against President Bashar al-Assad began in March 2011.
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